Glutathione detoxification anti-aging star effect ingredient

Glutathione yeast powder (now renamed "glutathione rich yeast") was officially approved as a common food raw material, can be officially approved as a common food raw material, can be added according to the actual needs of production.

Raw materials shall comply with the standard requirements of "Yeast Product Quality requirements Part 2: Yeast Processed Products" (GB/ T20886.2-2021).

Glutathione rich yeast as a food raw material has obtained a legal identity, which is good news for the industry, and has injected a new vitality into the innovative development of the food industry.

Glutathione yeast powder is a product derived from glutathione yeast as the main raw material under the action of yeast's own enzymes or additional food processing enzymes, enzymolysis, autolysis and separation after extraction through or without thermal processing, and contains amino acids, glutathione, nucleotides and other soluble ingredients in yeast cells belonging to food ingredients.

Glutathione is a tripeptide composed of L-glutamic acid, glycine and L-cysteine, which is widely found in animals, plants and microorganisms, and is one of the most important non-protein sulfhydryl compounds in living organisms.

Glutathione (GSH) is an abundant non-protein mercaptan in cells and one of the most abundant antioxidant substances in human body. It participates in REDOX reactions in vivo and has many physiological functions.

It has broad application market prospect in the fields of oral beauty and liver protection.

Oral beauty

The global oral beauty market is growing rapidly, having climbed to $6.5 billion in 2022, and is expected to further expand to $15 billion by 2032.

From a global perspective, the Asia-Pacific oral beauty products market share ranks first in the world, accounting for about 40%.

Japan and China are the major drivers of the oral beauty market in Asia Pacific.

At present, China's oral beauty industry is in a period of rapid growth, and it is predicted that by 2025, the market size of the industry is expected to exceed 25 billion yuan.

In recent years, with the rapid increase of social pressure, people of all generations generally suffer from bad living habits such as disturbed work and rest, poor diet, and lack of exercise, which can lead to sub-health problems such as poor skin condition.

Under the appearance level economy, consumers are eager to achieve both internal and external health maintenance through internal administration, and whitening and anti-aging have become the main concerns and demands of many consumers.

Glutathione has good antioxidant effect, can inhibit melanin formation and accelerate collagen synthesis.

Three enzymes are involved in the formation of melanin: tyrosinase (TYR), DHICA oxidase (TRP-1) and dopa pigment isomerase (TRP-2).

Tyrosinase is a copper protein, which is a key enzyme in the production of melanin, and the binuclear copper ion in its active center plays an important role in the enzyme catalysis.

Glutathione binds to the copper active site of tyrosinase, inactivates tyrosinase, and changes the direction of tyrosine synthesis of eumelanin to light yellow fusomelanin.

The unique sulfhydryl group of glutathione has strong antioxidant activity, which can clear ROS produced by epidermal cells after ultraviolet irradiation and reduce the formation of melanin induced by ROS.

Participants were selected to take glutathione tablets (100mg glutathione/tablet, 2 tablets a day) for one week, two weeks and four weeks for testing. Before the test, participants sat in the test environment for about 20 minutes.

Technicians used Mexameter®MX18 to measure the skin on the inner side of the forearm and the back neck for 5 times, and the average value was obtained. The changes of melanin and heme were analyzed by statistics of measured values.

The study found that compared with no use (week 0), the number of people with significant effective whitening effect gradually increased with the extension of taking time.

The overall melanin and heme decreased, and the heme decreased significantly.

According to the anti-aging study of glutathione-rich yeast on mouse skin [2], gavage experiments were conducted on mice at doses of 50mg, 100mg and 200mg per day corresponding to human intake.

The results showed that after gavage with different doses of yeast extract, the epidermal layer thickening of the skin tissue of mice was significantly improved, and the dermis recovered compared with the model group. The recovery of elastic fiber and collagen fiber was similar to that of positive group.

Consumption of yeast extract is mainly to reduce the antioxidant stress pathway to further achieve anti-aging effect, mainly to reduce MDA and other peroxides and improve the body's antioxidant defense system such as GSH-Px enzyme activity.

Cure wine and protect liver

According to the statistics of market institutions, from the interpretation of the liver protection market from 2022 to 2029, the incidence of liver disease is still on the rise globally.

In China, the prevalence of NAFLD in the general population is about 15% to 40%, which is far higher than the global average prevalence rate of 25.24%.

This indicates that for a long period of time in the future, the demand for liver protection and liver nourishing products will increase significantly.

According to Magic Mirror Market Intelligence data, sales in the liver care market from April 2022 to March 2023 increased by 104.7% year-on-year.

This is related to China's unique table wine culture, and data show that China has a liquor market of 100 billion and about 500 million wine people, which contains a blue ocean worth 100 billion.

Glutathione is a tripeptide of sulfhydryl group, which has antioxidant effect and integrated detoxification effect.

As one of the most important antioxidants in cells, one of the main functions of glutathione is to neutralize and remove these harmful active substances, thereby protecting cells from oxidative stress.

Glutathione exists in the human body in two reciprocal forms, reduced glutathione (GSH) and oxidized glutathione (GSSG).

GSH is the main form of the cell, as a powerful antioxidant, can strongly exclude toxic compounds and foreign substances, in this process, glutathione peroxidase continuously oxidizes GSH to GSSG.

In order to maintain intracellular REDOX balance, glutathione reductase produces GSH by reducing GSSG.

Glutathione is one of the most important antioxidants in cells, and one of its main functions is to neutralize and remove harmful active substances, thereby protecting cells from oxidative stress.

Glutathione (GSH) is highly concentrated in the liver.

Lower liver glutathione levels can further exacerbate and perpetuate ongoing liver damage.

Compared with the Control group, a large amount of lipid droplets were deposited in the liver cells of mice in the ALD group.

Compared with ALD group, L-G-YE and H-G-YE intervention can reduce hepatocyte lipid droplet deposition to varying degrees.

After the intervention of yeast extract, the serum ALT and AST levels can be significantly reduced, and the liver injury caused by alcohol can be effectively improved.

Meanwhile, the levels of TC and TG in serum and liver were significantly decreased.

The brown area of liver tissue in the yeast extract group was reduced to different degrees.

Quantitative analysis results showed that compared with ALD group, the expression level of F4/80 in L-G-YE group was significantly decreased, indicating that GYE can effectively improve the inflammatory infiltration of hepatocytes.

The approval of glutathione rich yeast will provide food manufacturers with more diversified choices, helping to promote the innovation and development of the food industry, consumers are not only concerned about a single raw material, more concerned about the combination of raw materials and scientific combination, not only concerned about the type of ingredients, and more aware of the effective amount of raw materials.

Market demand has a traction effect on the addition of raw materials, and targeted product positioning and rapid iteration are important starting points to promote the health care market according to the efficiency needs of consumer groups and the characteristics of life scenes.

Reference materials:

• 1. White Paper on Oral Beauty Market Trends 2024
• 2. Fu Shaowei, Qin Xiuyuan, ZHANG Zhuoran et al. Dietary yeast extract improves antioxidant level in mice with aging skin model by up-regulating Nrf-2 [J]. Food and Fermentation Industry, 2023.
• 3. Hao Han, Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function, Food Science and Human Wellness, 2024