Glutathione is involved in most chronic diseases

Glutathione is associated with most chronic diseases - Why rheumatoid arthritis? Is gout caused by an overdose of prin?

Rheumatoid arthritis (RA) is a difficult joint disease, the main symptom of the patient's joint synovial membrane inflammation, and can continue to spread, further erosion of the synovial membrane near the cartilage and hard bone, inflammation symptoms worsened into bone damage.

In the past, rheumatoid arthritis was often regarded as a disease with abnormal antigens, because in the process of inflammation, there will be a large number of immune cells in the synovial membrane at the joint, such as macrophages and B cells, fibroblasts and dendritic cells.

Recently, however, there is increasing evidence that the real cause of rheumatoid arthritis is related to reactive oxygen species and lipid peroxidation.

In other words, the abnormal inflammatory response of antigenic cells (T cells) in the synovial membrane of the patient is only a frustration against oxidative damage, and is related to glutathione consumption.

Glutathione is an important thiol in the cell, which has the ability of anti-oxidation and regulation of REDOX mechanism, and is also the main basis of antigenic cells (T cells) to resist oxidative damage.

However, the reactive oxygen species in the synovial membrane of rheumatoid arthritis, and the resulting peroxidation, deplete T cells of glutathione, and thus cause abnormal inflammatory responses of T cells.

cause of rheumatoid arthritis lies in the oxidative damage of reactive oxygen species: the abnormal inflammatory response of antigenic cells such as T cells is due to the REDOX order reflected by the consumption of glutathione by oxidative stress.

The real key to determining the cause of rheumatoid arthritis is the amount of glutathione, that is, the strength of the ability to fight oxidative stress.

Gout is a disease caused by the accumulation of uric acid, in which the monosodium salt of uric acid is a precursor to inflammation, so the symptoms of gout, in addition to causing severe pain at times, also accompanied by swelling and inflammation of the joints.

However, because uric acid crystals are water-soluble, even without special treatment, they will naturally dissolve over time, but long-term pain and inflammation will bring inconvenience to life, action and mood.

However, it must be clarified that the inflammatory response caused by uric acid only occurs in the early stage of gout, and the inflammatory symptoms in the later stage are less obvious.

The conversion mechanism is quite complex, and it is necessary to understand the dual characteristics of uric acid crystals:

Although uric acid crystals can direct the inflammatory response of prostaglandins, they can also convert the metabolism of arachidonic acid (AA, the substrate that triggers the inflammatory response of prostaglandins), so that AA metabolites are converted from inflammatory prostaglandins (PGS) to 1-2-HHT, so that prostaglandins are reduced.

Uric acid crystals also increase the concentration of glutathione inside and outside the cell, and as mentioned earlier, glutathione regulates COX enzymes (enzymes that affect the production of prostaglandins) and inhibits inflammation.

Although uric acid crystals are the main cause of gout symptoms and guide the initial inflammatory symptoms of gout, the later inflammatory symptoms can be resolved by the conversion of arachidonic acid metabolites in the inflammatory matrix and the increase of extracellular and extracellular glutathione concentration.

Of course, the role of interglutathione is quite important; Inhibiting prostaglandin synthesis by regulating COX enzymes to avoid inflammation plays an important role in relieving gout symptoms.

Therefore, the traditional idea that gout is caused by the overdose of prin is not completely correct, at least, the rise and fall of glutathione is also one of the reasons for regulating gout symptoms.