NMN may effective in preventing lung injury and inflammation caused swine flu and mycoplasma

Severe winter is prone to respiratory infectious diseases such as swine flu. Studies have found that NMN can help prevent and reduce lung injury, inhibit inflammatory pathways, and enhance immunity. Respiratory tract is not suitable for timely medical treatment, scientific health prevention, appropriate supplementation of dietary supplements such as NMN can strengthen the body's defense line.

As winter quietly approaches, the biting wind not only makes people shiver, but also provides a breeding ground for influenza A (H1N1) and mycoplasma and other influenza viruses.

Swine flu, an acute respiratory infection caused by the influenza A virus, is a threatening disease with a variety of symptoms, including sudden high fever, intense cough, sore throat, stuffy nose, persistent headache, and aching muscles all over the body.

These discomfort often spread rapidly through droplets with viruses in the respiratory tract, or through the mucous membranes of the mouth, nose and even eyes, and are transmitted directly or indirectly between people, making people impossible to prevent.

1. NMN may help prevent and alleviate lung injury

A study published in Nutrients, a top international journal, found that after increasing NAD+ level, lung tissue showed positive changes, inflammatory cells were significantly reduced, oxidative stress was reduced, and glutathione, which has antioxidant, meso-free radical and detoxification effects, was increased, confirming that NAD+ supplementation can help prevent or reduce lung injury and related inflammation.

NMN supplementation may be an effective ameliorative adjuvant strategy for alleviating silicosis, a common type of pneumoconiosis.

In experiments, the researchers introduced silica powder directly into the trachea of mice to induce silicosis.

The trachea was then injected daily with normal saline, low-dose NAD+ supplement (500mg/kg), and high-dose NAD+ supplement (1000mg/kg).

In addition, two control groups were set up, none of which were treated with silicosis, one normal saline control and one NAD+ supplement (1000mg/kg) control.

It was found that compared with normal mice in the control group, the lung weight coefficient, pathological score and collagen volume fraction of mice exposed to silica after 28 days were significantly increased, the lung tissue structure was seriously damaged, and the deposition of collagen fibers in the interstitial tissue was significantly increased, indicating that silica powder can indeed cause lung damage.

After 28 days of exposure to silica powder, lung weight coefficient, pathological score and collagen volume score of 5 groups of mice were measured

However, the lung tissue structure of mice in the low and high dose NAD+ supplement group was relatively complete, with only a few small inflammatory cell nodules, indicating that NAD+ supplementation can help alleviate lung injury induced by silica.

Through observation, the researchers also found that NAD+ can promote the entry of the antioxidant pathway Nrf2 into the nucleus, suggesting that NAD+ regulates the expression of antioxidant-related genes by promoting Nrf2 expression and nuclear translocation, which can help reduce lung oxidative damage.

Overall, this study provides evidence that NAD+ supplementation may prevent lung injury and reduce associated inflammation.

Other models of lung damage, such as lung damage due to sepsis and lung fibrosis due to cigarettes, have also been shown to have positive effects after NAD+ supplementation.

2. NMN can inhibit inflammatory pathways

Recent research from Tsinghua University shows that NMN may also have a positive effect on the activity of immune cells.

Through metabolomic analysis of activated macrophages, the Tsinghua University research team found that supplementing NMN not only increased the level of NAD in activated cells, but also reduced the production of cytokines.

In addition, NMN can also reduce the expression of inflammation-related proteins and inhibit inflammation-related pathways, thereby regulating their immune function.

These findings further support the idea that NMN may enhance the anti-cancer activity of immune cells.

When the body sends a signal of discomfort, especially when the respiratory tract infection symptoms, timely medical treatment is particularly important.

In view of the high incidence of respiratory infectious diseases, scientific health and preventive measures are essential.

Appropriate supplementation with dietary supplements such as NMN (beta-nicotinamide mononucleotide) can help strengthen the body's defense against viral invasion, reduce potential lung damage, and accelerate the recovery of physical function.